Since the atomic number of hydrogen is 1, a positive hydrogen ion (H+) has no electrons and corresponds to a bare nucleus with 1 proton (and 0 neutrons for the most abundant isotope 11H). In chemistry and biology therefore, the word "proton" is commonly used as a synonym for hydrogen ion (H+) or hydrogen nucleus in several contexts:
- The transfer of H+ in an acid-base reaction is referred to "proton transfer". The acid is referred to as a proton donor and the base as a proton acceptor.
- The hydronium ion (H3O+) in aqueous solution corresponds to a hydrated hydrogen ion. Often the water molecule is ignored and the ion written as simply H+(aq) or just H+, and referred to as a "proton". This is the usual meaning in biochemistry, as in the term proton pump which refers to a protein or enzyme which controls the movement of H+ ions across cell membranes.
- Proton NMR refers to the observation of hydrogen nuclei in (mostly organic) molecules by nuclear magnetic resonance. This method uses the spin of the proton, which has the value one-half.